Persistent Antigens Hypothesis: The Human Leukocyte Antigen (HLA) Connection
نویسندگان
چکیده
منابع مشابه
Evolution and Diversity of the Human Leukocyte Antigen(HLA)
Human leukocyte antigen (HLA) Class I and Class II antigens can be genetically extremely diverse, play a central role in immunity and are of primary importance in several branches of medicine. By presenting fragments of pathogens or altered ‘self’ proteins, HLA molecules activate T lymphocytes and are essential in adaptive immune responses against infection or cancer. Clinically, certain HLA ty...
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The three-dimensional (3D) structures of human leukocyte antigen (HLA) molecules are indispensable for the studies on the functions at molecular level. We have developed a homology modeling system named HLA-modeler specialized in the HLA molecules. Segment matching algorithm is employed for modeling and the optimization of the model is carried out by use of the PFROSST force field considering t...
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Background: During pregnancy, the maternal immune system is in close contact with cells and tissue from the semiallogenic fetus .The human leucocyte antigen (HLA) class Ib molecules, HLA-E, -F and -G, are expressed at the materno-fetal interface. Because of the apparent immunoregulatory functions of these proteins, they may be involved in successful acceptance of the semi-allogenic fetus during...
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Malignant conditions can affect any part of the gastrointestinal (GI) tract, including the esophagus, stomach, biliary system, pancreas, small intestine, large intestine, rectum and anus (1). Currently, conventional TNM staging is the most important prognostic factor for determining the clinical outcome of GI cancer. However, clinical studies have shown that patients with similar stages of the ...
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ژورنال
عنوان ژورنال: Journal of Neurology & Neuromedicine
سال: 2018
ISSN: 2572-942X
DOI: 10.29245/2572.942x/2018/6.1235